Yang, Jinchen; Chen, Ling; Dong, Yibo; Zhang, Jinli; Wu, Yangjie published an article in 2022, the title of the article was Di-tert-butyl peroxide (DTBP)-mediated synthesis of symmetrical N,N’-disubstituted urea/thiourea motifs from isothiocyanates in water.Application In Synthesis of 1,3-Diphenylurea And the article contains the following content:
A direct approach to N,N’-disubstituted urea/thiourea from the self-condensation reactions of isothiocyanates in water has been developed. This access tolerated a wide range of functional groups on the aromatic ring, providing a practical and environment-friendly process to N,N’-disubstituted urea/thiourea in moderate to excellent yields from safe and easily available starting materials. A plausible mechanism of the desulfurization self-condensation reaction for urea was also proposed and the role of di-tert-Bu peroxide (DTBP) and copper catalyst in the present strategy was demonstrated with the help of ESI mass spectrometry of intermediate studies. The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Application In Synthesis of 1,3-Diphenylurea
The Article related to urea thiourea preparation green chem, isothiocyanate desulfurization self condensation ditert butyl peroxide, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Ureas, Carbamic Acids, Guanidines, and Their Sulfur-Containing Analogs and other aspects.Application In Synthesis of 1,3-Diphenylurea
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