Wan, Yameng; Wu, Hao; Ma, Nana; Zhao, Jie; Zhang, Zhiguo; Gao, Wenjing; Zhang, Guisheng published an article in 2021, the title of the article was De novo design and synthesis of dipyridopurinone derivatives as visible-light photocatalysts in productive guanylation reactions.Related Products of 102-07-8 And the article contains the following content:
De novo design and synthesis of a series of 6H-dipyrido[1,2-e:2′,1′-i]purin-6-ones (DPs), e.g., I as a new class of visible-light photoredox catalysts (PCs) was described. The synthesized DPs showed their λAbs(max) values in 433-477 nm, excited state redox potentials E*1/2 red and E*1/2 ox in 1.15-0.69 eV and -1.41 to -1.77 eV (vs. SCE), resp. As a representative, DP I enabled productive guanylation of amines, including 1°, 2°, and 3°-alkyl primary amines, secondary amines, aryl and heteroaryl amines, amino-nitrile, amino acids and peptides as well as propynylamines and α-amino esters giving diversities in biol. important guanidines and cyclic guanidines. The photocatalytic efficacy of DP I in guanylation overmatched commonly used Ir and Ru polypyridyl complexes, and some organic PCs. Other salient merits of this method included broad substrate scope and functional group tolerance, gram-scale synthesis, and versatile late-stage derivatizations that led to a derivative 81 exhibiting 60-fold better anticancer activity against Ramos cells with IC50 of 0.086μM than that of clin. drug ibrutinib (5.1μM). The experimental process involved the reaction of 1,3-Diphenylurea(cas: 102-07-8).Related Products of 102-07-8
The Article related to dipyridopurinone photocatalyst preparation dft, guanidine photochem preparation antiproliferative, amine thiourea guanylation dipyridopurinone photocatalyst visible light induced and other aspects.Related Products of 102-07-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics