On June 1, 2022, Sai Kumar, Gobbilla; Bhattacharjee, Jayeeta; Kumari, Kusum; Moorthy, Shruti; Bandyopadhyay, Ayan; Kumar Singh, Saurabh; Panda, Tarun K. published an article.Category: amides-buliding-blocks The title of the article was Hydroboration of nitriles, esters, and amides catalyzed by simple neosilyllithium. And the article contained the following:
We present here an efficient method for the hydroboration of organic nitriles, carboxylic esters, and carboxamides with pinacolborane (HBpin) using an alkali metal catalyst, neosilyllithium (LiCH2SiMe3), in neat reaction conditions. The reactions were accomplished with efficient catalytic reactivity and demonstrated by neosilyllithium at room temperature, in solvent-free condition, to afford a high yield of the corresponding N-boryl amines, boryl ethers, and amine hydrochlorides. The protocol for the catalytic reaction presented in this paper is simple and efficient, with diverse substrate scope for nitriles, carboxylic esters, and carboxamides showing excellent functional group tolerance. DLPNO-CCSD(T) calculations were also performed, showing that the hydroboration of nitriles catalyzed by neosilyllithium occurs through the pre-coordination of the nitrile at Lewis acid lithium followed by hydride migration from the B-H entity. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Category: amides-buliding-blocks
The Article related to hydroboration nitrile ester amide preparation aralkyl amine alc, lithium organometallic catalyst hydroboration reduction nitrile ester amide, crystal mol optimized structure picolyl diborylamine and other aspects.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics