On September 30, 2022, Liman, Recep; Ali, Muhammad Muddassir; Istifli, Erman Salih; Cigerci, Ibrahim Hakki; Bonciu, Elena published an article.Formula: C2H4ClNO The title of the article was Genotoxic and cytotoxic effects of pethoxamid herbicide on Allium cepa cells and its molecular docking studies to unravel genotoxicity mechanism. And the article contained the following:
Pethoxamid is chloroacetamide herbicide. Pethoxamid is commonly used to kill different weeds in various crops. Pethoxamid can leach in the water and soil and can cause toxic effects to other non-target species. Current study is therefore aimed to perform the investigation of the cytotoxic and genotoxic effects of pethoxamid on Allium cepa cells. The root growth, mitotic index (MI), chromosomal aberrations (CAs), and DNA damage were assessed through root growth inhibition, A. cepa ana-telophase, and alk. comet assays, resp. Furthermore, mol. docking was performed to evaluate binding affinity of pethoxamid on DNA and very-long-chain fatty acid (VLCFA) synthases. In root growth inhibition test, onion root length was statistically significantly decreased in a concentration dependent manner. Concentration- and time-dependent decreases in MI were observed, whereas increase in CAs such as disturbed ana-telophase, chromosome laggards, stickiness, anaphase bridges, and DNA damage was caused by the pethoxamid on A. cepa root cells. Mol. docking revealed that pethoxamid binds selectively to GC-rich regions in the minor groove of the DNA structure and showed remarkable binding affinity against all synthases taking part in the sequential biosynthesis of VLCFAs. It was concluded that the pethoxamid-induced genotoxicity and cytotoxicity may be through multiple binding ability of this herbicide with DNA and VLCFA synthases. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Formula: C2H4ClNO
The Article related to pethoxamid herbicide allium cepa cell mol docking genotoxicity, binding affinity, chromosomal aberrations, dna damage, long-chain fatty acids, mitotic index, molecular docking, pethoxamid and other aspects.Formula: C2H4ClNO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics