Li, Li; Schug, Kevin A. published an article in 2014, the title of the article was Continuous-flow extractive desorption electrospray ionization coupled to normal phase separations and for direct lipid analysis from cell extracts.Computed Properties of 5455-98-1 And the article contains the following content:
Normal phase liquid chromatog. is a common mode for chiral separations Many chiral amines are used as drugs or are important intermediates for drug synthesis. Electrospray ionization mass spectrometry is well known for its high sensitivity. However, when using normal phase liquid chromatog., electrospray ionization is hampered by the poor ionization efficiency of analytes from organic eluents. Continuous-flow extractive desorption electrospray ionization, which introduces the eluents through a hypodermic needle into the electrospray plume is demonstrated here for its success to interface normal phase liquid chromatog. to mass spectrometry detection. Such an approach was shown to be as or more sensitive than UV detection for a selected set of aromatic amine-functionalized enantiomers. Also demonstrated is the direct infusion of cell extracts to monitor phospholipids from three different bacterial cells. Despite their presence in non-electrospray-ionization-friendly extraction solvents, continuous-flow extractive desorption electrospray ionization enabled the sensitive detection of phospholipids and the ability to tune ion forms through incorporation of different spray modifiers. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Computed Properties of 5455-98-1
The Article related to extractive desorption electrospray mass spectrometry lipid cell, liquid chromatog bacteria phospholipid, ambient ionization, chiral separation, direct analysis, mass spectrometry, phospholipids and other aspects.Computed Properties of 5455-98-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics