On June 4, 2022, Kumar, Vishal; Dhawan, Sanjeev; Bala, Renu; Girase, Pankaj Sanjay; Singh, Parvesh; Karpoormath, Rajshekhar published an article.Application In Synthesis of N,N-Diethylacetamide The title of the article was Metal-free direct annulation of 2-aminophenols and 2-aminothiophenols with unactivated amides through transamidation: Access to polysubstituted benzoxazole and benzothiazole derivatives. And the article contained the following:
Simple yet novel oxidant, metal and solvent-free green protocol for synthesizing differently 2-substituted 1,3-benzoxazoles I [R1 = Me, Ph, Bn, etc.; R2 = H, 6-Me, 5-Cl, etc.; X = O] and benzothiazoles I [R1 = Me; R2 = H, 5-Cl; X = S] from 2-aminophenol hydrochloride salt, unactivated amide as in situ carbon source was reported. Further, the hydrogen ion of hydrochloride played a crucial role in amide activation followed nucleophilic attack that through eliminations of amine as a side product, and de-hydrolysis step leads to final annulation. This versatile strategy was applicable to a wide variety of differently substituted o-aminophenols, unactivated aliphatic and aromatic amides, yielding the corresponding product in good to excellent yields in a single step. The experimental process involved the reaction of N,N-Diethylacetamide(cas: 685-91-6).Application In Synthesis of N,N-Diethylacetamide
The Article related to benzoxazole green preparation, aminophenol hydrochloride salt unactivated amide annulation, benzothiazole green preparation, aminothiophenol hydrochloride salt unactivated amide annulation and other aspects.Application In Synthesis of N,N-Diethylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics