Kakeya, Nobuharu; Yata, Noboru; Kamada, Akira; Aoki, Masaru published an article in 1969, the title of the article was Biological activities of drugs. VII. Structure-activity relations of sulfonamide carbonic anhydrase inhibitors. 2.Application of 97-09-6 And the article contains the following content:
Diuretic, natriuretic activities, and duration of the diuretic action in rats were studied with 22 sulfonamide derivatives To clarify the active form of the sulfonamides, the effect of pH of the rat body fluid on the diuretic activity was studied. The diuretic and natriuretic activities of the sulfonamides increased with an increase in their carbonic anhydrase inhibitory activity except for o-substituted benzenesulfonamides, disubstituted benzenesulfonamides, and 2-amino-1,3,4-thiadiazole-5-sulfonamide. A close relation between diuretic and natriuretic activities with the electronic characteristics of the sulfamoyl group, such as Hammett’s σ constant, pKa, NMR chem. shift of the sulfamoyl protons, and S:O valence-force constant was observed for the derivatives with some exceptions. A compound having a large partition coefficient and strong albumin binding ability showed long duration of the diuretic action. The diuretic and natriuretic activities of sulfonamides were enhanced by an increase in their dissociation constants The diuretic activity was enhanced under alkaline conditions. It was concluded that the active form of the sulfonamide carbonic anhydrase inhibitors was the ionized form. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Application of 97-09-6
The Article related to sulfonamides diuresis natriuresis, diuresis natriuresis sulfonamides, natriuresis sulfonamides diuresis, carbonic amhydrase drug, amhydrase carbonic drug, drug carbonic anhydrase and other aspects.Application of 97-09-6
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