On October 13, 2016, Ferguson, Fleur M.; Ni, Jing; Zhang, Tinghu; Tesar, Bethany; Sim, Taebo; Kim, Nam Doo; Deng, Xianming; Brown, Jennifer R.; Zhao, Jean J.; Gray, Nathanael S. published an article.COA of Formula: C9H10N2O The title of the article was Discovery of a Series of 5,11-Dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-ones as Selective PI3K-δ/γ Inhibitors. And the article contained the following:
Dual inhibition of PI3K-δ and PI3K-γ is an established therapeutic strategy for treatment of hematol. malignancies. Reported mols. targeting PI3K-δ/γ selectively are chem. similar and based upon isoquinolin-1(2H)-one or quinazolin-4(3H)-one scaffolds. Here we report a chem. distinct series of potent, selective PI3K-δ/γ inhibitors based on a 5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one scaffold with comparable biochem. potency and cellular effects on PI3K signaling. We envisage these mols. will provide useful leads for development of next-generation PI3K-δ/γ targeting therapeutics. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).COA of Formula: C9H10N2O
The Article related to pi3k delta gamma inhibitor benzopyrimidodiazepinone preparation structure activity kinome, pi3k-γ, pi3k-δ, kinase inhibitor, p110-γ, p110-δ, phosphatidylinositol-4,5-bisphosphate 3-kinase-delta and other aspects.COA of Formula: C9H10N2O
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