Xu, Shibo; Takamatsu, Kazutaka; Hirano, Koji; Miura, Masahiro published an article in 2018, the title of the article was Nickel-Catalyzed Stereospecific C-H Coupling of Benzamides with Epoxides.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione And the article contains the following content:
A Ni(OAc)2-catalyzed C-H coupling of 8-aminoquinoline-derived benzamides with epoxides has been developed. The reaction proceeds with concomitant removal of the 8-aminoquinoline auxiliary to form the corresponding 3,4-dihydroisocoumarins directly. Addnl., the nickel catalysis is stereospecific, and the cis- and trans-epoxides are converted into the corresponding cis- and trans-dihydroisocoumarins with retention of configuration, which is complementary to previously reported palladium catalysis. Moreover, while still preliminary, the Csp3-H functionalization is also achieved in the presence of modified NiCl2 catalysts. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione
The Article related to aminoquinoline benzamide epoxide nickel stereospecific coupling catalyst microwave irradiation, dihydroisocoumarin stereoselective preparation, c−h coupling, epoxides, lactones, nickel, stereospecificity and other aspects.Name: 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics