On May 1, 2015, Wan, Yichao; Wu, Shaolei; Xiao, Guizhi; Liu, Tingting; Hou, Xuben; Chen, Chen; Guan, Peng; Yang, Xinying; Fang, Hao published an article.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide The title of the article was Design, synthesis and preliminary bioactivity studies of 2-thioxo-4-thiazolidinone derivatives as Bcl-2 inhibitors. And the article contained the following:
The B-cell lymphoma-2 (Bcl-2) protein is a promising target for cancer therapy. In the present study, a series of 2-thioxo-4-thiazolidinone derivatives were designed and synthesized as Bcl-2 inhibitors. Most of them possessed decent inhibitory activity for anti-apoptotic Bcl-2 proteins. Among them, compound I has similar growth inhibition towards K562 compared to (R)-Gossypol. In addition, it inhibits the myeloid cell leukemia sequence 1 (Mcl-1) protein with a Ki value of 74 nM. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Quality Control of 3-Nitro-4-chlorobenzenesulfonamide
The Article related to thioxothiazolidinone derivative preparation preliminary bioactivity bcl2 inhibitor, oxothiazolidinethione derivative preparation preliminary bioactivity bcl2 inhibitor, cancer therapy growth inhibition thioxothiazolidinone derivative, 2-thioxo-4-thiazolidinone, anti-tumor, bcl-2, inhibitors and other aspects.Quality Control of 3-Nitro-4-chlorobenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics