On January 31, 2013, Spasov, A. A.; Yakovlev, D. S.; Suzdalev, K. F.; Kosolapov, V. A.; Kucheryavenko, A. F.; Gurova, N. A.; Grechko, O. Yu.; Naumenko, L. V.; Kolobrodova, N. A.; Mitina, T. M.; Mal’tsev, D. V.; Babakova, M. N. published an article.Category: amides-buliding-blocks The title of the article was Synthesis and pharmacological activity of amides of 2-amino-3-indolylacrylic acid. And the article contained the following:
Opening of the five-member ring of indolylmethyleneoxazolones with aliphatic amines was used to synthesize a series of amides of 2-amino-3-indolylacrylic acid. These compounds were studied in vitro in relation to the various types of pharmacol. activity typical of this class, including receptor (5-HT2-, 5-HT3-, and P2Y1-ergic, K-opioid), antiaggregant, hemorheol., antiarrhythmic, and antioxidant activities. The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).Category: amides-buliding-blocks
The Article related to purinoceptor 5ht receptor antiaggregant hemorheol antiarrhythmic antioxidant aminoindolylacrylamide preparation, acrylamide aminoindolyl preparation pharmacol activity, ring opening indolylmethyleneoxazolone aliphatic amine and other aspects.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics