On February 28, 2018, Sapegin, Alexander; Kalinin, Stanislav; Angeli, Andrea; Supuran, Claudiu T.; Krasavin, Mikhail published an article.Recommanded Product: 97-09-6 The title of the article was Unprotected primary sulfonamide group facilitates ring-forming cascade en route to polycyclic [1,4]oxazepine-based carbonic anhydrase inhibitors. And the article contained the following:
4-Chloro-3-nitrobenzenesulfonamide reacted cleanly at room-temperature with a range of bis-electrophilic phenols bearing an NH-acidic functionality (secondary carboxamide or pyrazole) in the ortho-position. This produced a novel class of [1,4]oxazepine-based primary sulfonamides which exhibited strong inhibition of therapeutically relevant human carbonic anhydrases. 2-Chloronitrobenzene did not enter a similar cyclocondensation process, even under prolonged heating. Thus, the primary sulfonamide functionality plays a dual role by enabling the [1,4]oxazepine ring construction and acting as a enzyme prosthetic zinc-binding group when the resulting [1,4]oxazepine sulfonamides are employed as carbonic anhydrase inhibitors. The experimental process involved the reaction of 3-Nitro-4-chlorobenzenesulfonamide(cas: 97-09-6).Recommanded Product: 97-09-6
The Article related to oxazepine primary sulfonamide preparation human carbonic anhydrase inhibitor, carbonic anhydrase inhibitors, electron-withdrawing group, isoform-selectivity, nucleophilic aromatic substitution, primary sulfonamide, reactivity-matched substrates, smiles rearrangement and other aspects.Recommanded Product: 97-09-6
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics