On August 16, 2022, Liang, Chao; Zhang, Shan; Robinson, David; Ploeg, Matthew Vander; Wilson, Rebecca; Nah, Jiemin; Taylor, Dale; Beh, Sheryl; Lim, Radiance; Sun, Lei; Muoio, Deborah M.; Stroud, David A.; Ho, Lena published an article.Product Details of 79-07-2 The title of the article was Mitochondrial microproteins link metabolic cues to respiratory chain biogenesis. And the article contained the following:
Electron transport chain (ETC) biogenesis is tightly coupled to energy levels and availability of ETC subunits. Complex III (CIII), controlling ubiquinol:ubiquinone ratio in ETC, is an attractive node for modulating ETC levels during metabolic stress. Here, we report the discovery of mammalian Co-ordinator of mitochondrial CYTB (COM) complexes that regulate the stepwise CIII biogenesis in response to nutrient and nuclear-encoded ETC subunit availability. The COMA complex, consisting of UQCC1/2 and membrane anchor C16ORF91, facilitates translation of CIII enzymic core subunit CYTB. Subsequently, microproteins SMIM4 and BRAWNIN together with COMA subunits form the COMB complex to stabilize nascent CYTB. Finally, UQCC3-containing COMC facilitates CYTB hemylation and association with downstream CIII subunits. Furthermore, when nuclear CIII subunits are limiting, COMB is required to chaperone nascent CYTB to prevent OXPHOS collapse. Our studies highlight CYTB synthesis as a key regulatory node of ETC biogenesis and uncover the roles of microproteins in maintaining mitochondrial homeostasis. The experimental process involved the reaction of 2-Chloroacetamide(cas: 79-07-2).Product Details of 79-07-2
The Article related to respiratory chain biogenesis mitochondrial microprotein homeostasis, cp: metabolism, cytb, seps, smim4, uqcc1, uqcc2, complex iii, electron transport chain, microproteins, nuclear-mitochondrial coordination, smorfs and other aspects.Product Details of 79-07-2
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