On August 2, 2018, Lee, Jun; Lee, Young Hun; Park, Byung Sun; Yoo, Hee Won published a patent.Recommanded Product: 16230-24-3 The title of the patent was Preparation of fused pyrimidine derivatives as multi-target kinase inhibitors. And the patent contained the following:
The present invention provides fused pyrimidine derivatives I [X = direct bond, O, NH, C(O) or heterocycloalkyl; Y = alkoxyalkyl, heterocycloalkyl or heterocycloalkylalkyl; W = O or NH; Z = A or B; R1 = H, alkoxy or halogen; R2 = H or dialkylaminoalkyl], or their pharmaceutically acceptable salts or stereoisomers, and pharmaceutical compositions containing them. For example, N-[3-[(2-chloro-6,7-dihydrothieno[3,2-d]pyrimidin-4-yl)oxy]phenyl]acrylamide (preparation given) was coupled with 4-[4-(pyrrolidin-1-yl)piperidin-1-yl]aniline (preparation given) to provide compound II. The invention compounds are useful as multi-target kinase inhibitors for the prevention or treatment of cancers or immune-related diseases such as rheumatoid arthritis, Sjoegren’s syndrome, psoriasis, systemic lupus erythematosus, atopy, asthma and multiple sclerosis. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Recommanded Product: 16230-24-3
The Article related to fused pyrimidine derivative preparation multitarget kinase inhibitor cancer treatment, immune related disease rheumatoid arthritis sjoegren syndrome psoriasis treatment, systemic lupus erythematosus atopy asthma multiple sclerosis treatment and other aspects.Recommanded Product: 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics