On April 15, 2016, Huang, Zhenhua; Zhang, Qian; Yan, Lianzhong; Zhong, Guizhen; Zhang, Linqi; Tan, Xiaojuan; Wang, Yanli published an article.Electric Literature of 16230-24-3 The title of the article was Approaching the active conformation of 1,3-diaminopyrimidine based covalent inhibitors of Bruton’s tyrosine kinase for treatment of Rheumatoid arthritis. And the article contained the following:
By applying conformational restrictions, the authors were able to discover highly potent 1,3-diaminopyrimidine based covalent inhibitors of BTK, such as (I) (IC50 = 3.76 nM), and providing useful information of its active conformation. The authors are developing these novel small mol. covalent inhibitors of BTK toward oral agents for Rheumatoid arthritis. The experimental process involved the reaction of N-(3-Aminophenyl)acrylamide(cas: 16230-24-3).Electric Literature of 16230-24-3
The Article related to diaminopyrimidine preparation conformation bruton tyrosine kinase inhibitor antirheumatic, 1,3-diamino-pyrimidine, bruton’s tyrosine kinase (btk), collagen-induced arthritis (cia), rheumatoid arthritis (ra) and other aspects.Electric Literature of 16230-24-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics