Hu, Yawen; Chen, Jianzhong; Li, Bowen; Zhang, Zhenfeng; Gridnev, Ilya D.; Zhang, Wanbin published an article in 2020, the title of the article was Nickel-Catalyzed Asymmetric Hydrogenation of 2-Amidoacrylates.SDS of cas: 27115-50-0 And the article contains the following content:
Earth-abundant nickel, coordinated with a suitable chiral bisphosphine ligand was found to be an efficient catalyst for the asym. hydrogenation of 2-amidoacrylates affording the chiral α-amino acid esters in quant. yields and excellent enantioselectivity (up to 96% ee). The active catalyst component was studied by NMR and HRMS, which helped us to realized high catalytic efficiency on a gram scale with a low catalyst loading (S/C=2000). The hydrogenated products could be simply converted into chiral α-amino acids, β-amino alcs. and their bioactive derivatives Furthermore, the catalytic mechanism was investigated using deuterium-labeling experiments and computational calculations The experimental process involved the reaction of 2-(4-Methylbenzamido)acetic acid(cas: 27115-50-0).SDS of cas: 27115-50-0
The Article related to amidoacrylate preparation nickel catalyst enantioselective hydrogenation, amido carboxylate preparation, 2-amidoacrylates, asymmetric hydrogenation, chiral α-amino acids, homogeneous catalysis, nickel and other aspects.SDS of cas: 27115-50-0
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics