On May 4, 2012, Hou, Wenduan; Zheng, Bo; Chen, Jun; Peng, Yungui published an article.COA of Formula: C15H15F3N2O2S The title of the article was Asymmetric Synthesis of Polysubstituted 4-Amino- and 3,4-Diaminochromanes with a Chiral Multifunctional Organocatalyst. And the article contained the following:
A series of multifunctional catalysts with two chiral diaminocyclohexane units were developed and successfully applied in the asym. oxa-Michael-aza-Henry cascade reaction of salicylaldimines with nitroolefins. This approach provides a simple and efficient entry to polysubstituted chiral 4-aminobenzopyrans with three consecutive stereocenters and in high yield (up to 97%) with excellent stereoselectivity (up to 98% ee and >99:1 dr). Facile access to the nonsym. optically pure 3,4-diaminochromanes was also obtained. The experimental process involved the reaction of N-[(1S,2S)-2-Amino-1,2-diphenylethyl]-1,1,1-trifluoromethanesulfonamide(cas: 167316-28-1).COA of Formula: C15H15F3N2O2S
The Article related to nitroolefin salicylaldimine chiral diaminocyclohexane thiourea asym michael henry, aminochromane stereoselective preparation, chiral diaminocyclohexane thiourea enantioselective diastereoselective michael henry catalyst and other aspects.COA of Formula: C15H15F3N2O2S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics