On January 22, 2015, Bottegoni, Giovanni; De Simone, Alessio; Ruda, Gian Filippo; Cavalli, Andrea; Bandiera, Tiziano; Piomelli, Daniele published a patent.Product Details of 5455-98-1 The title of the patent was Preparation of phenyl carbamates as inhibitors of the fatty acid amide hydrolase (FAAH) enzyme and modulators of the D3 dopamine receptor (D3DR). And the patent contained the following:
Disclosed are compounds I [Ar = aromatic or heteroaromatic single or fused ring comprising heteroatoms selected from N, O and S; R1, R2 = independently H, halo, alkyl, etc.; X = N or CH; Y = -CH2(CH2)nCH2- or -CH2CH:CHCH2- (wherein Y is optionally substituted by B) ; n = 0-3; B = F, OH, CH2OH, etc.; R3 = aromatic or heteroaromatic ring, benzyl, benzoyl (optionally substituted by R5), etc.; R5 = OH, NH2, CN, etc.; R4 = H, halo, alkyl, etc.; or R3 and R4, together with the Ph ring to which they are connected, may form 9H-carbazole ring; or pharmaceutically acceptable salts thereof]. For example, compound II was prepared by following general procedure: to a solution of Boc2O (1.4 equiv) in acetonitrile were added DMAP (1 equiv)/acetonitrile and an amine (1 equiv)/acetonitrile, the resulting mixture was stirred at room temperature for 10 min, treated with an alc. derivative (1.2-1.4 equiv) at room temperature for 22 h, concentrated in vacuo, dissolved in Et acetate, washed with saturated aqueous NaHCO3, dried over Na2SO4, concentrated, and purified. The exemplified compound II exhibited IC50 of 4.4 nM for human FAAH and EC50 of 14.0 nM for D3DR. Compounds I are claimed useful for the treatment of nicotine use disorders, substance abuse addiction, eating diorders, etc. The experimental process involved the reaction of 2-(Oxiran-2-ylmethyl)isoindoline-1,3-dione(cas: 5455-98-1).Product Details of 5455-98-1
The Article related to fatty acid amide hydrolase faah inhibitor phenyl carbamate preparation, d3 dopamine receptor d3dr modulator phenyl carbamate preparation, nicotine eating disorder substance abuse addiction treatment phenyl carbamate and other aspects.Product Details of 5455-98-1
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics