Category: amides-buliding-blocksOn September 16, 2016 ,《Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids》 was published in Organic Letters. The article was written by Zhu, Yan-Ping; Sergeyev, Sergey; Franck, Philippe; Orru, Romano V. A.; Maes, Bert U. W.. The article contains the following contents:
A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with com. reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols. In the experimental materials used by the author, we found 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Category: amides-buliding-blocks)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics