HPLC of Formula: 70-55-3In 2019 ,《Stereoselective synthesis of medium lactams enabled by metal-free hydroalkoxylation/stereospecific [1,3]-rearrangement》 was published in Nature Communications. The article was written by Zhou, Bo; Zhang, Ying-Qi; Zhang, Kairui; Yang, Ming-Yang; Chen, Yang-Bo; Li, You; Peng, Qian; Zhu, Shou-Fei; Zhou, Qi-Lin; Ye, Long-Wu. The article contains the following contents:
Here a metal-free intramol. hydroalkoxylation/[1,3]-rearrangement was reported, leading to the practical and atom-economical assembly of valuable medium-sized lactams such as I [R1 = Me, Et, Ph; R2 = Me, Ph, 2-naphthyl, etc.; R3 = 8-Me, 9-Cl, 8-Br, etc.; R4 = SO2Ph, Ts, Bs] with wide substrate scope and excellent diastereoselectivity. Moreover, such an asym. cascade cyclization was realized by chiral Bronsted acid-catalyzed kinetic resolution In addition, antitumor activity tests revealed that that some of these medium-sized lactams displayed their bioactivity as antitumor agents against melanoma cells, esophageal cancer cells and breast cancer cells. A mechanistic rationale for the reaction was further supported by control experiments and theor. calculations The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3HPLC of Formula: 70-55-3)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Many important products require amines as part of their syntheses. Methylamine is utilized in the production of the analgesic meperidine (trade name Demerol) and the photographic developer Metol (trademark), and dimethylamine is used in the synthesis of the antihistamine diphenhydramine (trade name Benadryl), the solvent dimethylformamide (DMF), and the rocket propellant 1,1-dimethylhydrazine. The synthesis of the insect repellent N,N-diethyl-m-toluamide (DEET) incorporates diethylamine while that of the synthetic fibre Kevlar requires aromatic amines.HPLC of Formula: 70-55-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics