《Copper-catalyzed carbonylative synthesis of β-homoprolines from N-fluoro-sulfonamides》 was published in Organic Letters in 2020. These research results belong to Zhang, Youcan; Yin, Zhiping; Wu, Xiao-Feng. Recommanded Product: 70-55-3 The article mentions the following:
A new methodol. for the carbonylative transformation of N-fluoro-sulfonamides into N-sulfonyl-β-homoproline esters has been described. In the presence of a catalytic amount of Cu(OTf)2, a range of β-homoproline derivatives were prepared in moderate to good yield. The reaction proceeds via the intramol. cyclization and intermol. carbonylation of a free carbon radical. Notably, this procedure offers the possibility to build potential functionalized bioactive mols. The experimental process involved the reaction of 4-Methylbenzenesulfonamide(cas: 70-55-3Recommanded Product: 70-55-3)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: 70-55-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics