Recommanded Product: N-Methoxy-N-methylacetamideIn 2018 ,《Discovery of Pyridopyrimidinones as Potent and Orally Active Dual Inhibitors of PI3K/mTOR》 appeared in ACS Medicinal Chemistry Letters. The author of the article were Yu, Tao; Li, Ning; Wu, Chengde; Guan, Amy; Li, Yi; Peng, Zhengang; He, Miao; Li, Jie; Gong, Zhen; Huang, Lei; Gao, Bo; Hao, Dongling; Sun, Jikui; Pan, Yan; Shen, Liang; Chan, Chichung; Lu, Xiulian; Yuan, Hongyu; Li, Yongguo; Li, Jian; Chen, Shuhui. The article conveys some information:
The identification and lead optimization of a series of pyridopyrimidinone derivatives are described as a novel class of efficacious dual PI3K/mTOR inhibitors, resulting in the discovery of (I). Compound I exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation in cell assays and good pharmacokinetic profile. Furthermore, compound I demonstrated in vivo efficacy in a PC-3M tumor xenograft model. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Recommanded Product: N-Methoxy-N-methylacetamide)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Recommanded Product: N-Methoxy-N-methylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics