The author of 《NHC ligand-enabled Ni-catalyzed reductive coupling of alkynes and imines using isopropanol as a reductant》 were Yao, Wei-Wei; Li, Ran; Li, Jiang-Fei; Sun, Juan; Ye, Mengchun. And the article was published in Green Chemistry in 2019. Computed Properties of C7H9NO2S The author mentioned the following in the article:
A nickel-catalyzed reductive coupling of alkynes and imines using readily available isopropanol as the reducing agent was developed. The use of a sterically bulky and electron-rich carbene ligand compound I significantly promoted the reaction, providing various multi-substituted allylic amines in 23-89% yield and the corresponding chiral ligand compound II afforded the products in 51-95% ee. The experimental part of the paper was very detailed, including the reaction process of 4-Methylbenzenesulfonamide(cas: 70-55-3Computed Properties of C7H9NO2S)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. To avoid the problem of multiple alkylation, methods have been devised for “blocking” substitution so that only one alkyl group is introduced. The Gabriel synthesis is one such method; it utilizes phthalimide, C6H4(CO)2NH, whose one acidic hydrogen atom has been removed upon the addition of a base such as KOH to form a salt.Computed Properties of C7H9NO2S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics