《Synergy of activating substrate and introducing C-H···O interaction to achieve Rh2(II)-catalyzed asymmetric cycloisomerization of 1,n-enynes》 was published in Science China: Chemistry in 2020. These research results belong to Wu, Rui; Chen, Kai; Ma, Jun; Yu, Zhi-Xiang; Zhu, Shifa. Formula: C4H9NO2 The article mentions the following:
The first Rh2(II)-catalyzed asym. cycloisomerization of activated enynes was reported to provide cyclopropane-fused tetrahydropyridines I [R = H, Me, CO2Et, Ph, etc.; R1 = H, Me; X = O, NMs, NTs, etc.; n = 1, 2] in good yields and excellent enantioselectivities under mild conditions. The activated group, CHZ (Z was electron-withdrawing group), in the enyne substrates exerted two synergetic roles, one was to activate alkyne for the cyclopropanation reaction and the other was to introduce the C-H···O interaction between substrate and catalyst (reducing the energy barrier of the reaction). This double-mode activation was supported by both d. functional theory calculations and exptl. tests. This strategy was also extended to other CH2Z (Z could be OH, OMe, F) as activating groups that made the CH2 more acidic so that the substrates could also form increased C-H···O interaction with the catalyst. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Formula: C4H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics