Wang, Jiawen; Zheng, Sujuan; Rajkumar, Subramani; Xie, Jinglei; Yu, Na; Peng, Qian; Yang, Xiaoyu published their research in Nature Communications on December 31 ,2020. The article was titled 《Chiral phosphoric acid-catalyzed stereodivergent synthesis of trisubstituted allenes and computational mechanistic studies》.Computed Properties of C11H22N2O4 The article contains the following contents:
Here-in, an enantioselective and diastereodivergent synthesis of trisubstituted allenes I (R = Et, nBu, Bn, etc.; R1 = nBu, Ph, thiophen-3-yl, etc.; R2 = Ph, 4-chlorophenyl, cyclohexyl, etc.; R3 = Me, Et, n-Pr, n-Bu, i-Bu) and II by asym. additions of oxazolones III to activated 1,3-enynes R2CH:C(CCR1)C(O)R3 enabled by chiral phosphoric acid (CPA) catalysis where the divergence of the allenic axial stereogenicity is realized by modifications of CPA catalysts was reported. D. functional theory (DFT) calculations are performed to elucidate the origin of diastereodivergence by the stacking- and stagger-form in the transition state (TS) of allene formation step, as well as to disclose a Munchnone-type activation mode of oxazolones II under Bronsted acid catalysis. After reading the article, we found that the author used H-Lys(Boc)-OH(cas: 2418-95-3Computed Properties of C11H22N2O4)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Computed Properties of C11H22N2O4
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics