Volpi, Stefano; Rozzi, Andrea; Rivi, Nicola; Neri, Martina; Knoll, Wolfgang; Corradini, Roberto published an article on February 5 ,2021. The article was titled 《Submonomeric strategy with minimal protection for the synthesis of C(2)-modified peptide nucleic acids》, and you may find the article in Organic Letters.Application In Synthesis of H-Lys(Boc)-OH The information in the text is summarized as follows:
A novel synthesis of C(2)-modified peptide nucleic acids (PNAs) is proposed, using a submonomeric strategy with minimally protected building blocks, which allowed a reduction in the required synthetic steps. N(3)-unprotected, D-Lys- and D-Arg-based backbones were used to obtain pos. charged PNAs with high optical purity, as inferred from chiral GC measurements. “”Chiral-box”” PNAs targeting the G12D point mutation of the KRAS gene were produced using this method, showing improved sequence selectivity for the mutated- vs wild-type DNA strand with respect to unmodified PNAs. The experimental part of the paper was very detailed, including the reaction process of H-Lys(Boc)-OH(cas: 2418-95-3Application In Synthesis of H-Lys(Boc)-OH)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Application In Synthesis of H-Lys(Boc)-OH
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics