In 2022,Tilby, Michael J.; Dewez, Damien F.; Pantaine, Loic R. E.; Hall, Adrian; Martinez-Lamenca, Carolina; Willis, Michael C. published an article in ACS Catalysis. The title of the article was 《Photocatalytic Late-Stage Functionalization of Sulfonamides via Sulfonyl Radical Intermediates》.Reference of 4-Methylbenzenesulfonamide The author mentioned the following in the article:
A plethora of drug mols. and agrochems. contain the sulfonamide functional group. However, sulfonamides are seldom viewed as synthetically useful functional groups. To confront this limitation, a late-stage functionalization strategy is described, which allows sulfonamides to be converted to pivotal sulfonyl radical intermediates. This methodol. exploits a metal-free photocatalytic approach to access radical chem., which is harnessed by combining pharmaceutically relevant sulfonamides with an assortment of alkene fragments. Addnl., the sulfinate anion can be readily obtained, further broadening the options for sulfonamide functionalization. Mechanistic studies suggest that energy-transfer catalysis (EnT) is in operation. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Reference of 4-Methylbenzenesulfonamide)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Left-handed and right-handed forms (mirror-image configurations, known as optical isomers or enantiomers) are possible when all the substituents on the central nitrogen atom are different (i.e., the nitrogen is chiral). With amines, there is extremely rapid inversion in which the two configurations are interconverted.Reference of 4-Methylbenzenesulfonamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics