In 2014,Sugimura, Takanori; Komatsu, Akira; Koseki, Yohei; Usuki, Toyonobu published 《Pr(OTf)3-promoted Chichibabin pyridine synthesis of isodesmosine in H2O/MeOH》.Tetrahedron Letters published the findings.Application of 71432-55-8 The information in the text is summarized as follows:
1,2,3,5-Tetrasubstituted pyridinium amino acid isodesmosine is a crosslinking amino acid of elastin and is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). Herein, we report an application of the Chichibabin pyridine synthesis to the total synthesis of isodesmosine. Specifically, the appropriate protected lysine and the corresponding aldehyde were reacted using Pr(OTf)3 in H2O/MeOH. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Application of 71432-55-8)
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Application of 71432-55-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics