The author of 《Metabolism of N-acylated and O-alkylated drugs by intestinal microflora during anaerobic incubation in vitro》 were Smith, G. E.; Griffiths, L. A.. And the article was published in Xenobiotica in 1974. COA of Formula: C8H9NO2 The author mentioned the following in the article:
Phenacetin [62-44-2] and derivatives of acetanilide were N-deacylated by rat cecal microflora, the deacylation of the latter being dependent on the nature and position of the substituents. Thus, p-alkylated or o-, m-, or p-hydroxylated derivatives were deacylated, whereas a p-aromatic or halide substituent or an aromatic acyl grouping prevented deacylation. A few O-alkylated compounds with a simple benzenoid structure were dealkylated by cecal microflora, but none of the N-alkylated drugs were dealkylated. In the experiment, the researchers used many compounds, for example, 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6COA of Formula: C8H9NO2)
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. Amides include many other important biological compounds, as well as many drugs like paracetamol, penicillin and LSD. Low-molecular-weight amides, such as dimethylformamide, are common solvents.COA of Formula: C8H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics