Safety of tert-Butyl N,N’-diisopropylcarbamimidateIn 2011 ,《(+)-Sorangicin A: evolution of a viable synthetic strategy》 was published in Tetrahedron. The article was written by Smith, Amos B. III; Dong, Shuzhi; Fox, Richard J.; Brenneman, Jehrod B.; Vanecko, John A.; Maegawa, Tomohiro. The article contains the following contents:
An effective, asym. total synthesis of the antibiotic (+)-sorangicin A has been achieved. Central to this venture was the development of first- and second-generation syntheses of the signature dioxabicyclo[3.2.1]octane core, the first featuring chemo- and stereoselective epoxide ring openings facilitated by a Co2(CO)6-alkyne complex, the second involving a KHMDS-promoted epoxide ring formation/opening cascade. Addnl. highlights include effective construction of the dihydro- and tetrahydropyran ring systems, resp., via a stereoselective conjugate addition/α-oxygenation protocol and a thioketalization/hydrostannane reduction sequence. Late-stage achievements entailed two Julia-Kocienski olefinations to unite three advanced fragments with high E-stereoselectivity, followed by a modified Stille protocol to introduce the Z,Z,E trienoate moiety, thereby completing the carbon skeleton. Mukaiyama macrolactonization, followed by carefully orchestrated Lewis and protic acid-promoted deprotections that suppressed isomerization and/or destruction of the sensitive (Z,Z,E)-trienoate linkage completed the first, and to date only, total synthesis of (+)-sorangicin A.tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Safety of tert-Butyl N,N’-diisopropylcarbamimidate) was used in this study.
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Safety of tert-Butyl N,N’-diisopropylcarbamimidate
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics