Rocca, Patrick; Marsais, Francis; Godard, Alain; Queguiner, Guy published an article in Tetrahedron. The title of the article was 《Connection between metalation and cross-coupling strategies. A new convergent route to azacarbazoles》.Computed Properties of C10H14N2O The author mentioned the following in the article:
New convergent synthesis of azacarbazoles through metalation, cross-coupling reaction, and intramol. substitution via (2-aminobenzene)boronic acid and ortho-fluoroiodopyridines are presented. Thus, 2-(HO)2BC6H4NHCOCMe3 coupled with pyridines I (X = F, Cl, Y = iodo, Z = H; X = H, Y = F, Z = iodo; X = H, Y = iodo, Z = F; X = iodo, Y = F, Z = H) to give the corresponding (pyridylphenyl)propanamides II (R = F, Cl). The 3-fluoro-4-pyridyl derivative of II was treated with pyridinium chloride under reflux to give β-carboline III. The α-, γ-, and δ-carbolines were prepared similarly. In the experiment, the researchers used many compounds, for example, 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Computed Properties of C10H14N2O)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Hydrogen peroxide (H2O2) and peroxy acids generally add an oxygen atom to the nitrogen of amines. With primary amines, this step is normally followed by further oxidation, leading to nitroso compounds, RNO, or nitro compounds, RNO2. Secondary amines are converted to hydroxylamines, R2NOH, and tertiary amines to amine oxides, R3NO.Computed Properties of C10H14N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics