Name: tert-Butyl N,N’-diisopropylcarbamimidateIn 2020 ,《Total Synthesis of (+)-Trachyspic Acid 19-n-Butyl Ester》 was published in Organic Letters. The article was written by Rafaniello, Alex A.; Rizzacasa, Mark A.. The article contains the following contents:
The first total synthesis of the alkyl citrate trachyspic acid 19-Bu ester (I) is described. A formal [2 + 2]-cycloaddition of the silylketene acetal derived from lactone II with di-n-butylacetylenedicarboxylate provided the cyclobutene diester III with a dr >20:1. Acid-mediated rearrangement of III followed by lactone ring-opening and ester protecting group manipulation eventually provided orthogonally protected aldehyde IV. A Nozaki-Hiyama-Kishi coupling between IV and vinyl iodide V followed by oxidation of the resultant allylic alc. gave an enone, which was converted into a triester (dr 6:1) by a spirocyclization/oxidative cleavage/elimination sequence. Removal of the t-Bu esters then afforded trachyspic acid 19-Bu ester I. In the experimental materials used by the author, we found tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Name: tert-Butyl N,N’-diisopropylcarbamimidate)
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Reduction of nitro compounds, RNO2, by hydrogen or other reducing agents produces primary amines cleanly (i.e., without a mixture of products), but the method is mostly used for aromatic amines because of the limited availability of aliphatic nitro compounds. Reduction of nitriles and oximes (R2C=NOH) also yields primary amines.Name: tert-Butyl N,N’-diisopropylcarbamimidate
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