In 2019,Synthesis included an article by Murre, Aleksandra; Erkman, Kristin; Kaabel, Sandra; Jarving, Ivar; Kanger, Tonis. Computed Properties of C2H4BrNO. The article was titled 《Diastereoselective [2,3]-Sigmatropic Rearrangement of N-Allyl Ammonium Ylides》. The information in the text is summarized as follows:
A diastereoselective method was developed for the [2,3]-sigmatropic rearrangement of N-allyl ammonium ylides R1CH=CHCH2NR2R3CH2C(O)R4 [R1 = H, Me, Ph, 2-thienyl, etc.; R2 = Me; R3 = Me, Bn; R2R3 = (CH2)4; R4 = OMe, NHBoc, N-pyrrolidinyl, etc.], affording rearrangement products CH2=CHCHR1CH(C(O)R4)NR2R3 in up to 95% isolated yields and 97:3 dr, most of the desired products were formed within 1 min. For the asym. reaction, a chiral auxiliary was introduced to the starting compound, affording the rearrangement product with high diastereoselectivities. In the experiment, the researchers used 2-Bromoacetamide(cas: 683-57-8Computed Properties of C2H4BrNO)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.Computed Properties of C2H4BrNO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics