Synthetic Route of C10H14N2OOn November 8, 2004 ,《Synthesis of optically active ring-A substituted tryptophans as IDO inhibitors》 appeared in Tetrahedron Letters. The author of the article were Li, Xiaoyan; Yin, Wenyuan; Sarma, P. V. V. Srirama; Zhou, Hao; Ma, Jun; Cook, James M.. The article conveys some information:
The first stereoselective synthesis of optically active 6-chloro-L-tryptophan, 5-nitro-D-tryptophan, 6-nitro-D-tryptophan, 5,6-dichloro-L-tryptophan, 6-aza-D-tryptophan, as well as the first synthesis of the optically active 7-methoxy-D-tryptophan with potential activity at IDO (IDO = indoleamine 2,3-dioxygenase) via the Schollkopf chiral auxiliary is described. In addition to this study using 2,2-Dimehtyl-N-pyridin-3-yl-propionamide, there are many other studies that have used 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Synthetic Route of C10H14N2O) was used in this study.
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. The reaction of alkyl halides, R―X, where X is a halogen, or analogous reagents with ammonia (or amines) is useful with certain compounds. Not all alkyl halides are effective reagents; the reaction is sluggish with secondary alkyl groups and fails with tertiary ones. Its usefulness is largely confined to primary alkyl halides (those having two hydrogen atoms on the reacting site).Synthetic Route of C10H14N2O
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics