Synthetic Route of C13H26N2O4On March 4, 2011, Ko, Eunhwa; Burgess, Kevin published an article in Organic Letters. The article was 《Pyrrole-based scaffolds for turn mimics》. The article mentions the following:
Two amino acid derived synthons were combined to give homopropargylic amines (I) (R1 = CH(Me)Et, iso-Pr, CH2C6H4OCH2Ph, R2 = i-Bu; R1 = CH(Me)Et, (CH2)2SMe, R2 = CH2C6H4OCH2Ph; R1 = CH(Me)OCH2Ph, R2 = H; Boc = tert-butoxycarbonyl). Platinum dichloride was used to cyclize these intermediates into pyrroles (II) (Boc, R1 and R2 are defined for I) which collapsed to the target secondary structure mimics (III) (R1 and R2 are defined for I) on treatment with base. Side chains of these compounds overlay with an idealized type III β-turn and with an inverse γ-turn. The experimental process involved the reaction of (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Synthetic Route of C13H26N2O4)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides.Synthetic Route of C13H26N2O4Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics