《Expanding Zirconocene Hydride Catalysis: In Situ Generation and Turnover of ZrH Catalysts Enabling Catalytic Carbonyl Reductions》 was written by Kehner, Rebecca A.; Hewitt, Matthew Christian; Bayeh-Romero, Liela. Electric Literature of C4H9NO2This research focused onzirconium hydride in situ preparation zirconocene dichloride hydrosilane; ketone aldehyde enone ynone lactone reduction zirconium hydride catalyst. The article conveys some information:
Despite the wide use and popularity of metal hydride catalysis, methods utilizing zirconium hydride catalysts remain underexplored. Here, authors report the development of a mild method for the in situ prepatation. and use of zirconium hydride catalysts. This robust method requires only 2.5-5 mol % of zirconocene dichloride in combination with a hydrosilane as the stoichiometric reductant and does not necessitate careful air- or moisture-free technique. A key finding of this study concerns an amine-mediated ligand exchange en route to the active zirconocene hydride catalyst. Mechanistic investigation supports the intermediacy of an oxo-bridged dimer precatalyst. The application of this method to the reduction of a wide variety of carbonyl-containing substrates, including ketones, aldehydes, enones, ynones, and lactones is demonstrated with up to 92% yield and exhibiting broad functional group tolerability. These findings open up alternative avenues for the catalytic application of chlorozirconocenes, potentially serving as the foundation for broader applications of zirconium hydride catalysis. In the experimental materials used by the author, we found N-Methoxy-N-methylacetamide(cas: 78191-00-1Electric Literature of C4H9NO2)
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Electric Literature of C4H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics