Karatzas, Anastasis; Haataja, Johannes S.; Skoulas, Dimitrios; Bilalis, Panayiotis; Varlas, Spyridon; Apostolidi, Panagiota; Sofianopoulou, Sosanna; Stratikos, Efstratios; Houbenov, Nikolay; Ikkala, Olli; Iatrou, Hermis published their research in Biomacromolecules on December 9 ,2019. The article was titled 《Macromolecular Architecture and Encapsulation of the Anticancer Drug Everolimus Control the Self-Assembly of Amphiphilic Polypeptide-Containing Hybrids》.Category: amides-buliding-blocks The article contains the following contents:
Macromol. architecture plays an important role in the self-assembly process of block copolymer amphiphiles. Herein, two series of stimuli-responsive amphiphilic 3-miktoarm star hybrid terpolypeptides and their corresponding linear analogs were synthesized exhibiting the same overall composition and mol. weight but different macromol. architecture. The macromol. architecture was found to be a key parameter in defining the morphol. of the nanostructures formed in aqueous solutions as well as to alter the self-assembly behavior of the polymers independently of their composition In addition, it was found that the assemblies prepared from the star-shaped polymers showed superior tolerance against enzymic degradation due to the increased corona block d. on the outer surface of the nanoparticles. Encapsulation of the hydrophobic anticancer drug Everolimus resulted in the formation of intriguing non-spherical and non-sym. pH-responsive nanostructures, such as “”stomatocytes”” and “”multi-compartmentalized suprapolymersomes””, while the pH-triggered release of the drug was also investigated. Owing to the similarities of the developed “”stomatocytes”” with red blood cells, in combination with their pH-responsiveness and superior stability over enzymic degradation, they are expected to present advanced drug delivery properties and have the ability to bypass several extra- and intracellular barriers to reach and effectively treat cancer cells.H-Lys(Boc)-OH(cas: 2418-95-3Category: amides-buliding-blocks) was used in this study.
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Category: amides-buliding-blocks
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics