Formula: C4H9NO2In 2020 ,《Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors》 appeared in Bioorganic Chemistry. The author of the article were Jin, Ru-Yi; Tang, Tian; Zhou, Sha; Long, Xu; Guo, Hui; Zhou, Jing; Yan, Hao; Li, Zhi; Zuo, Zheng-Yu; Xie, Hong-Lei; Tang, Yu-Ping. The article conveys some information:
PI3Kα has been identified as an ideal target to treat with PIK3CA gene mutation disease, including drugs such as Alpelisib and Copanlisib. Five purine analogs and four thiazole analogs were designed and synthesized. Their enzymic activity against PI3Ka/β/γ/δ were tested, resp. All compounds showed excellent selectivity in modulating PI3Ka activity, and parts of the compounds showed good inhibition. Meanwhile, Autodock 4.2 was used to explore the binding mode of I (X = CH2), the most potent compound, with the target protein. In addition, DFT was used to calculate the HOMO-LUMO maps of the compounds I (X = CH2, O)and pos. control. This paper will provide some useful information for further drug design of PI3Kα inhibitors. In addition to this study using N-Methoxy-N-methylacetamide, there are many other studies that have used N-Methoxy-N-methylacetamide(cas: 78191-00-1Formula: C4H9NO2) was used in this study.
N-Methoxy-N-methylacetamide(cas: 78191-00-1) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Formula: C4H9NO2
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics