《A highly selective chemical probe for activin receptor-like kinases ALK4 and ALK5》 was written by Hanke, Thomas; Wong, Jong Fu; Berger, Benedict-Tilman; Abdi, Ismahan; Berger, Lena Marie; Tesch, Roberta; Tredup, Claudia; Bullock, Alex N.; Mueller, Susanne; Knapp, Stefan. COA of Formula: C2H4BrNO And the article was included in ACS Chemical Biology in 2020. The article conveys some information:
The transforming growth factor beta-receptor I/activin receptor-like kinase 5 (TGFBR1/ALK5) and its close homolog ALK4 are receptor protein kinases associated with the development of diverse diseases, including cancer, fibrosis, heart diseases, and dysfunctional immune response. Therefore, ALK4/5 are among the most studied kinases, and several inhibitors have been developed. However, current com. available inhibitors either lack selectivity or have not been comprehensively characterized, limiting their value for studying ALK4/5 function in cellular systems. To this end, we report the characterization of the 2-oxo-imidazopyridine, TP-008, a potent chem. probe with dual activity for ALK4 and ALK5 as well as the development of a matching neg. control compound TP-008 has excellent cellular potency and strongly abrogates phosphorylation of the substrate SMAD2 (mothers against decapentaplegic homolog 2). Thus, this chem. probe offers an excellent tool for mechanistic studies on the ALK4/5 signaling pathway and the contribution of these targets to disease. In the part of experimental materials, we found many familiar compounds, such as 2-Bromoacetamide(cas: 683-57-8COA of Formula: C2H4BrNO)
2-Bromoacetamide(cas: 683-57-8) can be used in preparation of (2-carbamoylmethoxy-5-chloro-benzyl)-carbamic acid tert-butyl ester. It was aslo used as precursor to dehydropeptidase I inactivator.COA of Formula: C2H4BrNO
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics