Recommanded Product: 2-Hydroxy-N-phenylacetamideOn May 31, 2008, Gomez, Maria J.; Sirtori, Carla; Mezcua, Milagros; Fernandez-Alba, Amadeo R.; Agueera, Ana published an article in Water Research. The article was 《Photodegradation study of three dipyrone metabolites in various water systems: Identification and toxicity of their photodegradation products》. The article mentions the following:
The photochem. behavior of 3 relevant metabolites of the analgesic and antipyretic drug dipyrone, 4-methylaminoantipyrine (4-MAA), 4-formylaminoantipyrine (4-FAA) and 4-acetylaminoantipyrine (4-AAA), was evaluated under simulated solar irradiation (Suntest system). For 4-MAA, different aqueous solutions (synthetic seawater, freshwater and Milli-Q water) as well as different operational conditions were compared. According to the exptl. results, 4-MAA resulted as being an easily degraded mol. by direct photolysis, with half-life times (t1/2) ranging from 0.12 to 0.58 h, depending on the irradiation conditions. Faster degradation was observed in synthetic waters, suggesting that the photolysis was influenced by the salt composition of the waters. However, no effect on the degradation rate was observed by the presence of natural photosensitizers (dissolved organic matter, nitrate ions). 4-FAA and 4-AAA showed slower photodegradation kinetics, with t1/2 of 24 and 28 h, resp. A study of photoproduct identification was carried out by gas chromatog.-mass spectrometry (GC-MS) and liquid chromatog.-time-of-flight mass spectrometry (LC-TOF-MS) (ESI pos. mode), which allowed us to propose a tentative photodegradation pathway for 4-MAA and the identification of persistent byproducts in all the cases. The application of an acute toxicity test (Daphnia magna) showed an increase in toxicity during the photolytic process, a consequence of the formation of toxic photoproducts. The results came from multiple reactions, including the reaction of 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Recommanded Product: 2-Hydroxy-N-phenylacetamide)
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Recommanded Product: 2-Hydroxy-N-phenylacetamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics