Application of 70298-88-3On June 10, 1988, Estel, L.; Marsais, F.; Queguiner, G. published an article in Journal of Organic Chemistry. The article was 《Metalation/SRN1 coupling in heterocyclic synthesis. A convenient methodology for ring functionalization》. The article mentions the following:
Sequential lithiation and iodination of 2-fluoropyridine gave 85% 2-fluoro-3-iodopyridine, which underwent nucleophilic aromatic substitution with NaOMe, NH3, and MeNH2 to give 70-96% 2-substituted 3-iodopyridines I (R = iodo; R1 = OMe, NH2, NHMe). Radical nucleophilic substitution reactions of these compounds with the enolates of MeCOCMe3 or Me2CO gave pyridylmethyl ketones I (R = CH2COCMe3, CH2COMe; same R1). Intramol. cyclocondensation of I (R = CH2COCMe3, CH2COMe; R1 = NH2, NHMe) gave pyrrolo[2,3-b]pyridines II (R2 = H, Me; R3 = CMe3, Me). Similar iodination, radical nucleophilic enolate substitution, and cyclocondensation starting from 2-, 3-, and 4-(pivaloylamino)pyridines gave 2-substituted pyrrolo[2,3-b]-, -[2,3-c]-, and -[3,2-c]pyridines [e.g., II (R2 = H, R3 = CMe3, Me), III]. The experimental part of the paper was very detailed, including the reaction process of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Application of 70298-88-3)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Application of 70298-88-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics