Related Products of 87694-50-6On October 15, 1991 ,《Conformational studies on bombesin antagonists: CD and NMR characterization of [Thr6, Leu13ψ(CH2NH)Met14] bombesin (6-14)》 was published in Biopolymers. The article was written by Di Bello, Carlo; Scatturin, Angelo; Vertuani, Gianni; D’Auria, Gabriella; Gargiulo, Mario; Paolillo, Livio; Trivellone, Enrico; Gozzini, Luigia; DeCastiglione, Roberto. The article contains the following contents:
The conformational flexibility of the [Thr6, Leu13ψ(CH2NH) Met14] bombesin (6-14) nonapeptide was studied by CD and 1- and 2-dimensional (1D and 2D) NMR techniques. The CD and NMR parameters in different solvents and in a micellar environment (SDS) are compared with the data collected for the parent bombesin (BN) and [D-Phe12, Leu14]BN. A preliminary investigation on spantide is also reported. In particular, the results obtained from CD measurements indicate that there is a shift from random coil structures, in aqueous solutions, toward folded structures in apolar media (2,2,2-trifluoroethanol) and in a membrane-mimetic environment (40 mM SDS) for all 3 peptides, namely BN, [D-Phe12, Leu14]BN, and [Thr6, Leu13ψ(CH2NH)Met14] BN (6-14). Spantide, which also possesses some inhibitory activity against BN but very little sequence similarity, even in water, shows an ordered conformation. NMR parameters such as backbone NH-α-CH coupling constant values, amidic temperature coefficients, and the presence of only sequential nuclear Overhauser effects have not provided, so far, any clear evidence for a preferential ordered structure in the peptides studied, and this may be due to rapid exchange among different conformers in the NMR time scale. In the part of experimental materials, we found many familiar compounds, such as (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Related Products of 87694-50-6)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. Because of the greater electronegativity of oxygen, the carbonyl (C=O) is a stronger dipole than the N–C dipole.Related Products of 87694-50-6 The presence of a C=O dipole and, to a lesser extent a N–C dipole, allows amides to act as H-bond acceptors. In primary and secondary amides, the presence of N–H dipoles allows amides to function as H-bond donors as well.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics