In 2010,Peptide Science included an article by Deguchi, Ayaka; Hattori, Yasunao; Konno, Hiroyuki; Nosaka, Kazuto; Akaji, Kenichi. Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide. The article was titled 《Syntheses of hydroxyethylamine derivatives containing side-chain mimetic substituent and peptide sequence》. The information in the text is summarized as follows:
A symposium report. Aspartic protease (AP) plays an essential role in serious diseases such as AIDS, ATL (Adult T-cell Leukemia), and Alzheimer’s disease, and is thought to be a suitable target to design therapeutic inhibitors. In the present study, we developed a synthetic route using Mannich-type reaction to construct hydroxyethylamine scaffold containing side-chain mimetic substituent and peptide sequence. After reading the article, we found that the author used (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide)
(S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide(cas: 87694-50-6) belongs to amides. The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.Recommanded Product: (S)-N-Methyl-N-methoxy-2-(tert-butoxycarbonylamino)-4-methylpentanamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics