In 2016,Heteroatom Chemistry included an article by Chiang, Kun-Heng; Lu, Shi-Han; Yen, Wan-Ping; Uramaru, Naoto; Tseng, Wei-Siou; Chang, Te-Wei; Wong, Fung Fuh. Synthetic Route of C8H9NO2. The article was titled 《Effective Synthesis of N-Arylformamide from α-Halo-N-arylacetamides》. The information in the text is summarized as follows:
A convenient synthetic method for N-arylformamide derivatives was successfully developed by reacting α-iodo-N-arylacetamides with formamide [e.g., α-iodo-N-phenylacetamide + HCONH2 → N-phenylformamide (94%)]. This method was applicable to α-iodo-N-arylacetamide substrates bearing electron-donating or electron-withdrawing groups, N-(benzo[d][1,3]dioxol-5-yl)-2-iodoacetamide, 2-iodo-N-(pyridin-2-yl)acetamide, and 2-iodo-N-(naphthalen-4-yl)acetamide to give the corresponding N-arylformamides in moderate to excellent yields (65-94%). A plausible mechanism was proposed to account for the new transformation. In addition to this study using 2-Hydroxy-N-phenylacetamide, there are many other studies that have used 2-Hydroxy-N-phenylacetamide(cas: 4746-61-6Synthetic Route of C8H9NO2) was used in this study.
2-Hydroxy-N-phenylacetamide(cas: 4746-61-6) belongs to amides.Synthetic Route of C8H9NO2Amides are pervasive in nature and technology. Proteins and important plastics like Nylons, Aramid, Twaron, and Kevlar are polymers whose units are connected by amide groups (polyamides); these linkages are easily formed, confer structural rigidity, and resist hydrolysis.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics