In 2020,Future Medicinal Chemistry included an article by Cao, Yucheng; Ni, Jingxuan; Ji, Wentao; Shang, Kangle; Liang, Kaicheng; Lu, Jing; Bi, Yi; Luo, Xiaomin. Recommanded Product: 2418-95-3. The article was titled 《Synthesis, antifungal activity and potential mechanism of fusidic acid derivatives possessing amino-terminal groups》. The information in the text is summarized as follows:
Aim: Fusidic acid (FA) is a narrow-spectrum bacteriostatic antibiotic. We inadvertently discovered that a FA derivative modified by an amino-terminal group at the 3-OH position, namely 2, inhibited the growth of Cryptococcus neoformans. Methods & results: Multiscale mol. modeling approaches were used to analyze the binding modes of 2 with eEF2. FA derivatives modified at the 3-OH position were designed based on in silico models; seven derivatives possessing different amino-terminal groups were synthesized and tested in vitro for antifungal activity against C. neoformans. Conclusion: Compound 7 had the strongest min. inhibitory concentration Two protonated nitrogen atoms of 7 interacted with a neg. electrostatic pocket of eEF2 likely explain the superiority of 7-2. In the part of experimental materials, we found many familiar compounds, such as H-Lys(Boc)-OH(cas: 2418-95-3Recommanded Product: 2418-95-3)
H-Lys(Boc)-OH(cas: 2418-95-3) belongs to amino acids. In addition to subunits of proteins, amino acids have many other functions as well, including osmoregulation (proline), neurotransmitters (gamma-aminobutyric acid), metabolic intermediates (ornithine and citrulline), and inhibitors (dehydroproline).Recommanded Product: 2418-95-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics