《Stereoselective organo-catalyzed glycosylation – thiouracil, thioureas and mono-thio-phthalimide act as Bronsted acid catalysts at low loadings》 was written by Bradshaw, G. A.; Colgan, A. C.; Allen, N. P.; Pongener, I.; Boland, M. B.; Ortin, Y.; McGarrigle, E. M.. Synthetic Route of C7H9NO2SThis research focused ontrehalose disaccharide synthesis stereoselective glycosylation catalyst Schreiner thiourea; hydrogen bonding Bronsted acid base catalysis deoxyglycoside glycoconjugate synthesis; stereoselective glycosylation catalyst galactal thiouracil thiophthalimide amino acid. The article conveys some information:
Thiouracil catalyzes stereoselective glycosylations with galactals in loadings as low as 0.1 mol%. It is proposed that in these glycosylation thiouracil, monothiophthalimide, and the previously reported catalyst, Schreiner′s thiourea, do not operate via a double H-bonding mechanism but rather by Bronsted acid/base catalysis. In addition to the synthesis of 2-deoxyglycosides and glycoconjugates, we report the first organo-catalytic synthesis of 1,1′-linked trehalose-type sugars.4-Methylbenzenesulfonamide(cas: 70-55-3Synthetic Route of C7H9NO2S) was used in this study.
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Reaction with nitrous acid (HNO2), which functions as an acylating agent that is a source of the nitrosyl group (―NO), converts aliphatic primary amines to nitrogen and mixtures of alkenes and alcohols corresponding to the alkyl group in a complex process. This reaction has been used for analytical determination of primary amino groups in a procedure known as the Van Slyke method.Synthetic Route of C7H9NO2S
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics