Bonnet, Veronique; Mongin, Florence; Trecourt, Francois; Queguiner, Guy published their research in Perkin 1 on December 21 ,2000. The article was titled 《Reaction of magnesiated bases on substituted pyridines: deprotonation or 1,4-addition?》.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide The article contains the following contents:
N-(tert.-Butyl)pyridine-2-carboxamide, N-phenylpyridine-2-carboxamide, and 2,2-dimethyl-N-(2-pyridyl)propanamide are readily deprotonated at C-3 with a stoichiometric amount of iso-PrMgCl or Bu2Mg in THF under reflux. Subsequent trapping with various electrophiles (deuterated water, aldehydes, iodine and di-Me disulfide) gives 2,3-disubstituted pyridines carrying a useful carboxylic acid- or amino-derived function at C-2. When N-(tert.-butyl)pyridine-3-carboxamide and 2,2-dimethyl-N-(3-pyridyl)propanamide are subjected to the same reaction conditions, 1,4-addition to the pyridine ring occurs, giving 4-alkyl derivatives Starting from N-(tert-butyl)pyridine-4-carboxamide, 1,2-addition and deprotonation reactions occur simultaneously. In the part of experimental materials, we found many familiar compounds, such as 2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide)
2,2-Dimehtyl-N-pyridin-3-yl-propionamide(cas: 70298-88-3) belongs to anime. Amines have a free lone pair with which they can coordinate to metal centers. Amine–metal bonds are weaker because amines are incapable of backbonding, but they are still important for sensing applications.While stronger than hydrogen bonds, amine–metal bonds are still weaker than both covalent and ionic bonds.Quality Control of 2,2-Dimehtyl-N-pyridin-3-yl-propionamide
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics