Recommanded Product: 106392-48-7On March 28, 1994, Blake, Robert A.; Asselin, Judith; Walker, Trevor; Watson, Steve P. published an article in FEBS Letters. The article was 《Fcγ receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor》. The article mentions the following:
The authors report that activation of phospholipase C (PLC) by crosslinking of the platelet low-affinity Fcγ receptor II (FcγRII) is inhibited by two structurally distinct tyrosine kinase inhibitors, staurosporine and ST 271. This contrasts with PLC activation induced by thrombin and U 46619, a thromboxane mimetic, whose receptors have seven transmembrane domains characteristic of G-protein coupled receptors. Several proteins undergo phosphorylation on tyrosine on FcγRII crosslinking upstream of protein kinase C (PKC), Ca2+ and aggregation, including the FcγRII itself. The role of FcγRII phosphorylation in the regulation of PLC is discussed. The experimental part of the paper was very detailed, including the reaction process of 2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7Recommanded Product: 106392-48-7)
2-Cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide(cas: 106392-48-7) belongs to amides.Recommanded Product: 106392-48-7 The solubilities of amides and esters are roughly comparable. Typically amides are less soluble than comparable amines and carboxylic acids since these compounds can both donate and accept hydrogen bonds.
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics