Related Products of 71432-55-8In 2020 ,《Sevanol and its analogues: chemical synthesis, biological effects and molecular docking》 was published in Pharmaceuticals. The article was written by Belozerova, Olga A.; Osmakov, Dmitry I.; Vladimirov, Andrey; Koshelev, Sergey G.; Chugunov, Anton O.; Andreev, Yaroslav A.; Palikov, Victor A.; Palikova, Yulia A.; Shaykhutdinova, Elvira R.; Gvozd, Artem N.; Dyachenko, Igor A.; Efremov, Roman G.; Kublitski, Vadim S.; Kozlov, Sergey A.. The article contains the following contents:
In this work, the efficient chem. synthesis scheme of sevanol I [R = H] and its analogs I [R = Me], II and III which allowed us to analyze the structure-activity relationships of the different parts of this mol. was described. We found that the inhibitory activity of sevanol and its analogs on ASIC1a and ASIC3 channels depends on the number and availability of the carboxyl groups of the mol. At the structural level, it was predicted the presence of a sevanol binding site based on the presence of mol. docking in the central vestibule of the ASIC1a channel. Also it was predicted that this site could also be occupied in part by the FRRF-amide peptide, and the competition assay of sevanol with this peptide confirmed this prediction. The i.v. (i.v.), intranasal (i.n.) and, especially, oral (p.o.) administration of synthetic sevanol in animal models produced significant analgesic and anti-inflammatory effects. Both non-invasive methods of sevanol administration (i.n. and p.o.) showed greater efficacy than the invasive (i.v.) method, thus opening new horizons for medicinal uses of sevanol. In addition to this study using tert-Butyl N,N’-diisopropylcarbamimidate, there are many other studies that have used tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8Related Products of 71432-55-8) was used in this study.
tert-Butyl N,N’-diisopropylcarbamimidate(cas: 71432-55-8) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Related Products of 71432-55-8
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics