Related Products of 70-55-3In 2019 ,《High-Throughput Discovery and Evaluation of a General Catalytic Method for N-Arylation of Weakly Nucleophilic Sulfonamides》 was published in Organic Letters. The article was written by Becica, Joseph; Hruszkewycz, Damian P.; Steves, Janelle E.; Elward, Jennifer M.; Leitch, David C.; Dobereiner, Graham E.. The article contains the following contents:
Through targeted high-throughput experimentation (HTE), authors have identified the Pd/AdBippyPhos catalyst system as an effective and general method to construct densely functionalized N,N-diaryl sulfonamide motifs relevant to medicinal chem. AdBippyPhos is particularly effective for the installation of heteroaromatic groups. Computational steric parametrization of the investigated ligands reveals the potential importance of remote steric demand, where a large cone angle combined with an accessible Pd center is correlated to successful catalysts for C-N coupling reactions. In the part of experimental materials, we found many familiar compounds, such as 4-Methylbenzenesulfonamide(cas: 70-55-3Related Products of 70-55-3)
4-Methylbenzenesulfonamide(cas: 70-55-3) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Related Products of 70-55-3
Referemce:
Amide – Wikipedia,
Amide – an overview | ScienceDirect Topics